Peptide Database

Peptide NameSLAY-screened peptide P2468

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H164N22O25S2

DescriptionStandard

        THSPLVSFIMPPPLTPLCLV
    

Molecular Weight2162.66 Da

Isoelectric Point (pI)6.40

Net Charge (pH 7.0)-0.52

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0262

GRAVY Index1.05

Hydrophobic Moment 0.25

Boman Index0.48

Instability Index82.33

Aliphatic Index 126.50

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 681.87

LogP -2.68

H-bond Donors 22.0

H-bond Acceptors 28.0

Rotatable Bonds 58.0

Heavy Atoms 151.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0164806 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/