Peptide Database

Peptide NameSLAY-screened peptide P4374

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC98H149N23O28S

DescriptionStandard

        SCGPYYIVVRTYDNGLPLV
    

Molecular Weight2129.43 Da

Isoelectric Point (pI)5.55

Net Charge (pH 7.0)-0.55

Net Charge (pH 7.4) -0.78

Charge Density (pH 7.0) -0.0290

GRAVY Index0.33

Hydrophobic Moment 0.52

Boman Index0.24

Instability Index43.35

Aliphatic Index 107.37

Aromaticity 0.1579

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 812.98

LogP -5.73

H-bond Donors 29.0

H-bond Acceptors 29.0

Rotatable Bonds 61.0

Heavy Atoms 150.0

Ring Count 5.0

Amide Bonds 19.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0325397 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/