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MYP_135910
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Basic Information
Brevinin-1Bd
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C122H198N28O26S2
Standard
Sequence
FLPAIAGVAAKFLPKIFCAISKKC
Physicochemical Analysis
2537.18 Da
9.70
3.74
3.50
0.1557
1.15
0.60
0.38
30.12
114.17
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-2.73
30.0
32.0
81.0
178.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044802 VERIFIED: YES
Provenance & Taxonomy
Rana berlandieri [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
7.0 μM
MIC
PaperJ. Goraya et al. / Eur. J. Biochem. 267 (2000) 894-900. Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0069569 VERIFIED: YES
Provenance & Taxonomy
Lithobates berlandieri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0077514 VERIFIED: YES
Provenance & Taxonomy
Rana berlandieri [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0091364 VERIFIED: YES
Provenance & Taxonomy
Lithobates berlandieri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0113580 VERIFIED: YES
Provenance & Taxonomy
Lithobates pipiens [Animal]
Brevinin
8404
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
3 μM
MIC
PaperPeptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens. PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
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