Peptide Database

Peptide NameHEVE_HEVBR

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length204 amino acids

Chemical FormulaC940H1425N267O303S17

DescriptionStandard

        ANKPYSWRSKYGWTAFCGPVGAHGQSSCGKCLSVTNTGTGAKTTVRIVDQCSNGGLDLDVNVFRQLDTDGKGYERGHITVNYQFVDCGDSFNPLFSVMKSDHNCQSNCKDSGEGVGGGSASNVLATYHLYNSQDHGWDLNAASAYCSTWDMNIFIVVLLCLTGVAIAEQCGRQAGGKLCPNNLCCSQWGWCGSTDEYCSPSVIN
    

Molecular Weight21859.08 Da

Isoelectric Point (pI)5.64

Net Charge (pH 7.0)-3.91

Net Charge (pH 7.4) -4.61

Charge Density (pH 7.0) -0.0192

GRAVY Index-0.26

Hydrophobic Moment 0.64

Boman Index0.06

Instability Index26.42

Aliphatic Index 63.53

Aromaticity 0.0980

Extinction Coeff. Reduced 44920.00

Extinction Coeff. Oxidized 45795.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243875 VERIFIED: YES

Provenance & Taxonomy

OrganismHevea brasiliensis [Plant]

FamilyHevein-like peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralityall-D amino-acid peptide [D]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Signaling Enzyme inhibitory ACE inhibitory Antihypertensive

TargetAngiotensin-converting enzyme