‹ ›
MYP_135860
← PREVIOUS NEXT → BACK
Basic Information
C6a
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Standard
6 amino acids
C43H59N11O9
Standard
Sequence
DWVRWI
Physicochemical Analysis
874.00 Da
5.84
-0.24
-0.44
-0.0398
-0.18
0.92
0.11
89.65
113.33
0.3333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
339.60
0.71
13.0
9.0
24.0
63.0
4.0
5.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0037256 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Fusion inhibition
Feline immunodeficiency virus (FIV) | lymphoid cells
0.06-0.15 μg/mL
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperStructural basis of antiviral activity of peptides from MPER of FIV gp36 | Grimaldi M, Stillitano I, Amodio G, Santoro A, Buonocore M, Moltedo O, Remondelli P, D'Ursi AM. | PLoS One. 2018 Sep 21;13(9):e0204042 | DOI:10.1371/journal.pone.0204042 | PMID:30240422 PMID30240422 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30240422/
RECORD: Rec_0083227 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
FIV-Pet(Feline immunodeficiency virus Pet):inhibition of virus replication in MBM cells
0.07 μg/mL
IC50
PaperPubMed PMID: 12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
RECORD: Rec_0086265 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0093172 VERIFIED: YES
Provenance & Taxonomy
Feline immunodeficiency virus [Virus]
Virus-derived peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Replication inhibitor
Feline immunodeficiency virus (Replication); MBM
0.171623 μM
ELISA
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
RECORD: Rec_0155848 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-FIV Entry inhibition
FIV-Pet (Feline immunodeficiency virus Pet) | MBM cells
0.07 μg/mL
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperAntiviral activity and conformational features of an octapeptide derived from the membrane-proximal ectodomain of the feline immunodeficiency virus transmembrane glycoprotein. | Giannecchini S, Di Fenza A, D'Ursi AM, Matteucci D, Rovero P, Bendinelli M. | J Virol. 2003 Mar;77(6):3724-33. | DOI:10.1128/jvi.77.6.3724-3733.2003 | PMID:12610147 PMID12610147 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12610147/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2