Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2277H3538N560O665S19

DescriptionStandard

        MEAMKILILWGYFLLWNPLTQSTQLYPGIKVRITQKGLDYGIQAAMEAIEVIMKTNGIPDFKGSESLDFLKVDYVDYNFSNIKINMFSFPNISLTPVPETGIKILTNHGSTNISMGWEIMSPLLKDGGGATLFLGEIFFSGLGNLSRSDTGHPSMHLVDCHVQVGHAHISFSGELSALYNSFAHPMEKPILKTLNKRLCTIITDQFEEINANISSLEVVTKFGEDVVLDYSLLEPPEITQSSIDLQLKGTFYPVENFTDPPFQPDPFTLPERSDSMLYLGISEYFFKSASFAYFTTGAFDITLTTKELYKHLIQNPQGIGSLFSQIAELYIMSRPLMVRILTTEPPVINLEPNNFTLNIPASIVMMTKPKNTTEEVIVSMDFMASTSVDLAIFGQRLICSLSLNRFQLSGPESNRSSIEVLRFENILSSILHFGVIPLANGKDFSKAH
    

Molecular Weight50007.04 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-14.59

Net Charge (pH 7.4) -15.47

Charge Density (pH 7.0) -0.0326

GRAVY Index0.08

Hydrophobic Moment 0.61

Boman Index0.17

Instability Index41.69

Aliphatic Index 96.83

Aromaticity 0.1027

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 35995.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296816 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodelphis domestica [Animal]

FamilyBPI

Tax ID13616

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence