Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length457 amino acids

Chemical FormulaC2265H3548N584O675S20

DescriptionStandard

        MMVNPVRNDMAREAVTERTLELALEDPKTILTPTPVSSPRHIPIITYVYKDGPSPLGVFPPVECLHLICLDHTPWNQGKDYSAGSGLCIKINALSFPNTSLAFVPGVGVKALTNHGTANISTHWEVKSPLFQDSGGADLFLSGVYFAGILTLTRNDLGQPNLELQDCHAQVSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIITGEVEALNANLSMLEVLTKIDNYTLLDYSLMSSPEITENYIDLNLKGAFYPLENLADPPFSPVPFELPERSDSMLYIGISEYFFKSASFAHFAAGAFNVTLSTKEISSHLVRNSQGVGNILSRIAEIYILSQPFMVRIMATEPPVISLLPGNFTLDIPASIMLLTQSENSTAETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPESNRDNIESSDPTQIQHVFQYCKHFQSKRELGRAKNCWI
    

Molecular Weight50401.21 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-15.46

Net Charge (pH 7.4) -16.50

Charge Density (pH 7.0) -0.0338

GRAVY Index0.05

Hydrophobic Moment 0.65

Boman Index0.14

Instability Index44.93

Aliphatic Index 98.14

Aromaticity 0.0832

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36370.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078028 VERIFIED: NO

Provenance & Taxonomy

OrganismMyotis davidii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence