Peptide Database

Peptide NameMT-SC34EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC205H331N51O66S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKSEEQQKKNEKELK
    

Molecular Weight4598.19 Da

Isoelectric Point (pI)5.42

Net Charge (pH 7.0)-1.48

Net Charge (pH 7.4) -1.73

Charge Density (pH 7.0) -0.0411

GRAVY Index-1.95

Hydrophobic Moment 0.69

Boman Index-0.48

Instability Index63.11

Aliphatic Index 54.17

Aromaticity 0.0833

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1994.09

LogP -13.68

H-bond Donors 67.0

H-bond Acceptors 66.0

Rotatable Bonds 173.0

Heavy Atoms 323.0

Ring Count 5.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0315306 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity0.001±0.0002 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0404229 VERIFIED: YES