Peptide Database

Peptide NameS18

Function Ontology

Immunology ▸ Cytokine / receptor signaling modulation ▸ TLR inhibition

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC166H281N61O36S2

DescriptionStandard

        MFTILEEYFMYRGLLGLRIRRRRRRRRR
    

Molecular Weight3771.52 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)8.50

Net Charge (pH 7.4) 8.28

Charge Density (pH 7.0) 0.3037

GRAVY Index-0.96

Hydrophobic Moment 0.47

Boman Index-0.61

Instability Index198.09

Aliphatic Index 83.57

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1665.21

LogP -12.08

H-bond Donors 67.0

H-bond Acceptors 47.0

Rotatable Bonds 132.0

Heavy Atoms 265.0

Ring Count 4.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0065909 VERIFIED: YES

Provenance & Taxonomy

OrganismOrthopoxvirus vaccinia [Virus]

FamilyP13/A52R-derived

Tax ID10245.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Anti-inflammatory TLR inhibitor

TargetCpG- or LPS-stimulated RAW264.7 macrophage assays