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MYP_135552
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Basic Information
Mycobacterial tuberculosis DHFR tripeptide analog
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Renin inhibition ▸ Renin inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
3 amino acids
C24H28N4O6
Standard
Sequence
WYT
Physicochemical Analysis
468.50 Da
5.52
-0.24
-0.45
-0.0803
-0.97
0.29
0.34
-21.63
0.00
0.6667
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
177.77
0.42
7.0
6.0
10.0
34.0
3.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium tuberculosis
MIC
PMID19697148 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19697148/
RECORD: Rec_0171562 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
3483.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive Renin inhibitory
Renin
PaperGirgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.. Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384-394.
RECORD: Rec_0204432 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
3483.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
54.0
PaperGirgih AT, He R, Aluko RE.. Kinetics and molecular docking studies of the inhibitions of angiotensin converting enzyme and renin activities by hemp seed (Cannabis sativa L.) peptides. J. Agric. Food Chem. 62, 4135?4144, 2014.
RECORD: Rec_0342795 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
3483.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperGirgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.. Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384-394.
RECORD: Rec_0384586 VERIFIED: YES
Provenance & Taxonomy
Cannabis sativa [Plant]
ACE inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme
0.574 μM
IC50
PaperPubMed PMID 24766098 PMID24766098 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24766098/
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