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MYP_135521
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Basic Information
Tigerinin-1 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
11 amino acids
C61H94N14O14S3
Standard
Sequence
FCTMIPIPRCY
Physicochemical Analysis
1343.68 Da
8.06
0.74
0.51
0.0672
0.82
0.32
0.28
26.64
70.91
0.1818
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
439.10
-1.20
17.0
18.0
37.0
92.0
4.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023904 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
2-10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0030114 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Tigerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
2-10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
30.0 μM
MIC
PaperK.P. Sai et al. / The Journal of Biological Chemistry 276 (2001) 2701-2707. Tigerinins: Novel Antimicrobial Peptides from the Indian Frog Rana tigerina Evidence URLhttps://www.uniprot.org/uniprotkb/P82651/entry
RECORD: Rec_0037872 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0044115 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
2-10
It contains one disulfide bond
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
HepG2
35.7 μM
IC50
PaperTigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
RECORD: Rec_0060653 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
2-10
It contains one disulfide bond
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Micrococcus luteus MT 166
20 μg/mL
MIC
PaperTigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina.
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