Peptide Database

Peptide NameSLAY-screened peptide P3818

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H172N36O30S

DescriptionStandard

        SRTPTSARRQLKNMNKEHLF
    

Molecular Weight2414.75 Da

Isoelectric Point (pI)11.72

Net Charge (pH 7.0)3.55

Net Charge (pH 7.4) 3.29

Charge Density (pH 7.0) 0.1774

GRAVY Index-1.45

Hydrophobic Moment 0.68

Boman Index-0.50

Instability Index61.23

Aliphatic Index 44.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1121.34

LogP -14.14

H-bond Donors 40.0

H-bond Acceptors 36.0

Rotatable Bonds 83.0

Heavy Atoms 169.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0179128 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/