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MYP_135444
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Basic Information
Apidaecin IA
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
18 amino acids
C95H150N32O23
Standard
Sequence
GNNRPVYIPQPRPPHPRI
Physicochemical Analysis
2108.41 Da
11.71
2.85
2.59
0.1581
-1.41
0.32
-0.28
53.16
59.44
0.0556
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
869.16
-8.22
27.0
27.0
57.0
150.0
8.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0234718 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Apidaecin
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
B.thuringiensis tenebrionis DSM 2803
>200 μg/mL
MIC
PaperApidaecins: antibacterial peptides from honeybees.
RECORD: Rec_0254091 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium
0.1 μg/mL
MIC
PMID2676519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2676519/
RECORD: Rec_0254651 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Apidaecin
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
S.marcescens ATCC 17991
>200 μg/mL
MIC
PaperApidaecins: antibacterial peptides from honeybees.
RECORD: Rec_0262196 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1 IIIB | CEM-SS cells
47.7 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr. | Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6. | DOI:10.1128/AAC.01448-09 | PMID:20086159 PMID20086159 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20086159/
RECORD: Rec_0271133 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella Newport
0.2 μg/mL
MIC
PMID2676519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2676519/
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