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MYP_135444
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Basic Information
Apidaecin IA
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
18 amino acids
C95H150N32O23
Standard
Sequence
GNNRPVYIPQPRPPHPRI
Physicochemical Analysis
2108.41 Da
11.71
2.85
2.59
0.1581
-1.41
0.32
-0.28
53.16
59.44
0.0556
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
869.16
-8.22
27.0
27.0
57.0
150.0
8.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0126458 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium
150 μg/mL
MIC
PMID2676519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2676519/
RECORD: Rec_0130358 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Apidaecin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0135250 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
7460
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Shigella flexneri
0.1 μg/mL
MIC
PMID2676519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2676519/
RECORD: Rec_0138513 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Erwinia salicis
0.02 μg/mL
MIC
PMID2676519 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2676519/
RECORD: Rec_0141034 VERIFIED: YES
Provenance & Taxonomy
Apis mellifera [Animal]
Apidaecin
7460
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
A. tumefaciens DSM 3129
0.2 μg/mL
MIC
PaperApidaecins: antibacterial peptides from honeybees.
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