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MYP_135442
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Basic Information
P18
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C118H186N28O19
Standard
Sequence
KWKLFKKIPKFLHLAKKF
Physicochemical Analysis
2300.92 Da
10.78
6.84
6.58
0.3800
-0.38
0.82
-0.07
-9.94
92.22
0.2222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
775.84
1.67
27.0
27.0
80.0
165.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0175205 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200 μM
MHC
Paperhttps://pubmed.ncbi.nlm.nih.gov/18855761/ PMID18855761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18855761/
RECORD: Rec_0200383 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
K-562
3.5 μM
IC50
PaperAntibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. J Pept Res. 2001 Dec;58(6):504-14. doi: 10.1034/j.1399-3011.2001.00934.x. PMID: 12005420. | PubMed PMID: 12370027 PMID12005420;12370027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12005420/
RECORD: Rec_0204633 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0205134 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
A-375
80 μM
Cell viability assay
PMID19957017 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19957017/
RECORD: Rec_0205931 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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