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MYP_135442
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Basic Information
P18
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C118H186N28O19
Standard
Sequence
KWKLFKKIPKFLHLAKKF
Physicochemical Analysis
2300.92 Da
10.78
6.84
6.58
0.3800
-0.38
0.82
-0.07
-9.94
92.22
0.2222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
775.84
1.67
27.0
27.0
80.0
165.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0130356 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
PaperAntibiotic activity of reversed peptides of alpha-helical antimicrobial peptide, P18
RECORD: Rec_0137366 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
P18 and analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial
M14 (skin cancer)
80 μM
Cell viability assay
PaperAnti-melanoma activity of hybrid peptide P18 and its mechanism of action | https://pubmed.ncbi.nlm.nih.gov/19957017/ PMID19957017 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19957017/
RECORD: Rec_0151910 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
P18 and analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial
M14 (skin cancer)
60 μM
Cell viability assay
PaperAnti-melanoma activity of hybrid peptide P18 and its mechanism of action | https://pubmed.ncbi.nlm.nih.gov/19957017/ PMID19957017 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19957017/
RECORD: Rec_0154267 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
A-375
10 μM
Cell viability assay
PMID19957017 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19957017/
RECORD: Rec_0156801 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
None
Amidation
Bio-Activity Profile
Antimicrobial Hemolytic
Human erythrocytes
500 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21343499/ PMID21343499 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21343499/
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