MYP_135428
Dermonecrotic toxin LgSicTox-alphaIC1 (EC 4.6.1.-) (Phospholipase D) (PLD) (Phospholipase D LgRec1) (Sphingomyelin phosphodiesterase D) (SMD) (SMase D) (Sphingomyelinase D) [Cleaved into: U1-sicaritoxin-Lg1a (U1-SCRTX-Lg1a) (Anionic antimicrobial peptide) (AAMP) (Lg-AMP1)]
Anticancer
▸
Cytotoxic anticancer activity
▸
Cytotoxic
Antimicrobial
Antimicrobial
▸
Antibiotic activity
Antimicrobial
▸
Antifungal
Antimicrobial
▸
Antifungal
▸
Anti-Candida
Enzyme / Catalytic activity
▸
Lyase
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Toxicity / Safety
▸
Cytolysis / cell lysis
▸
Cytolytic activity
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Cytotoxic
Venom / Toxin
▸
General toxin
▸
Toxin
Standard
280 amino acids
C1397H2168N384O430S7
Standard
ADNRRPIWVMGHMVNSLAQIDEFVGLGSNSIETDVSFDKQANPEYTYHGIPCDCGRACLHSTKFNDFLKGLRKVTTPGDSKYLEKLILVVFDLKTGSLYDNQAYDAGTKLAKNLLQHYWNNGNNGGRAYIILSIPNLNHYKLITGFKETLKNEGHEELLEKVGTDFSGNDDISDVQKTYNKAGVTGHVWQSDGITNCLLRGLTRVKAAVANRDSGSGIINKVYYWTVDKRQSTRDTLDANVDGIMTNYPDITVEILNEAAYKKKFRIATYEDNPWETFKG
31446.93 Da
6.42
-1.61
-2.30
-0.0057
-0.52
0.83
-0.03
24.03
80.43
0.1000
48360.00
48610.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
RECORD: Rec_0334180
VERIFIED: YES
Provenance & Taxonomy
Loxosceles gaucho [Animal]
Arthropod phospholipase D; Class II subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Antibiotic
Antifungal
Anti-Candida
Lyase
Cytolytic
Toxin
Cytotoxic
Hemolytic
L. gaucho