Peptide Database

Peptide Namea4 (IG-19 analogs)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC115H207N35O20

DescriptionStandard

        IGKKFKRIVKRIKKFLRKL
    

Molecular Weight2400.10 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)9.75

Net Charge (pH 7.4) 9.54

Charge Density (pH 7.0) 0.5133

GRAVY Index-0.54

Hydrophobic Moment 1.07

Boman Index-0.42

Instability Index26.63

Aliphatic Index 117.89

Aromaticity 0.1053

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 954.96

LogP -3.18

H-bond Donors 36.0

H-bond Acceptors 30.0

Rotatable Bonds 92.0

Heavy Atoms 170.0

Ring Count 2.0

Amide Bonds 18.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0323489 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa (KCTC 1637)

Activity8 μM

MethodMIC

PaperProkaryotic selectivity and LPS-neutralizing activity of short antimicrobial peptides designed from the human antimicrobial peptide LL-37. Peptides. 2012 Jun;35(2):239-247. doi: 10.1016/j.peptides.2012.04.004. PMID: 22521196. PMID22521196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22521196/

RECORD: Rec_0407895 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus KCTC 1621

Activity4 μM

MethodMIC

FIRST PREV 1 2 3 4

Showing 2 records on this page Ã‚Â· Page 4 of 4