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MYP_135332
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Basic Information
mini-ChBac7.5N alpha
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C124H224N58O23
Standard
Sequence
RRLRPRRPRLPRPRPRPRPRPR
Physicochemical Analysis
2895.48 Da
12.00
11.76
11.56
0.5345
-2.69
0.38
-1.24
112.99
35.45
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1346.90
-14.12
51.0
35.0
87.0
205.0
8.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0356898 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
9925
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
methicillin-resistant Staphylococcus aureus ATCC 33591
64 μM
MIC
PMID27795854 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795854/
RECORD: Rec_0359005 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
MRSA (ATCC 33591)
0.7 ± 0.2μM without NaCl;MIC> 50μM 100 mM NaCl;MIC>64μM Broth microdilution assay
MIC
PMID27795854 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795854/
RECORD: Rec_0376562 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Surprisingly, the P8A analog became 8 fold less active
64 μM
MIC
PaperMinibactenecins ChBac7.Nalpha and ChBac7. Nbeta - Antimicrobial Peptides from Leukocytes of the Goat Capra hircus
RECORD: Rec_0390528 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Listeria monocytogenes (EGD)
0.2 ± 0.1μM without NaCl;MIC=1.0 ± 0.2μM 100 mM NaCl;MIC=2μM Broth microdilution assay
MIC
PMID27795854 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27795854/
RECORD: Rec_0391980 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
S-aureus ATCC 25923 or 710A or MRSA
>64 μM
MIC
PaperMinibactenecins ChBac7.Nalpha and ChBac7. Nbeta - Antimicrobial Peptides from Leukocytes of the Goat Capra hircus
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