Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2347H3807N611O647S18

DescriptionStandard

        MFPWRWLALLALIPLALSANAGVKVKLTQKGLDFGRELAVASLQKKLMTIKVPDISGKERVKPIGKVRYSVTEMRVVKLGLPSSAIGLVPGTGFSLTITNAFLSLHGRWRVKYLRFIKDRGSFDLAIKSLSITTSISLRSDNMGLPAVAMASCTTTLGGVSVKLHGGASWLYNLFRRFIEKGLQSQLQKKLCPLVAESVSSMNQFLKTVKVMAPVDRYAEIAYPMVSSPDISSSSIGLNLKGEFYNIGNHMEPPFSPAPFFLPNQEQSMLYIGLSAFTANSASFVYNKAGTLSLKITDDMVPRSSPIRLTTNTFGVLIPQIAKLFPGLMMVLQLKMTKDPLSSIEANKVTVDAKSSLTAYAILANTKLAPLFVLNLDFSVSARVNVVGNKLAGAVTLNRLDMSLGKSYVGDFKVGSLSNIFQIVLKWVVLPTVNVRLKEGFPLPSLGKINLKNTQLQILKGYIMIGTDLQNSG
    

Molecular Weight51513.21 Da

Isoelectric Point (pI)10.05

Net Charge (pH 7.0)27.74

Net Charge (pH 7.4) 27.25

Charge Density (pH 7.0) 0.0587

GRAVY Index0.24

Hydrophobic Moment 0.81

Boman Index0.15

Instability Index38.36

Aliphatic Index 107.57

Aromaticity 0.0803

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205342 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence