Peptide Database

Peptide NamecHLH-p53R

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC191H328N62O48S

DescriptionStandard

        GARELRRLERELRRLEGGGGGGGKLAALKFKLLWLKLAC
    

Molecular Weight4293.10 Da

Isoelectric Point (pI)10.91

Net Charge (pH 7.0)5.76

Net Charge (pH 7.4) 5.53

Charge Density (pH 7.0) 0.1476

GRAVY Index-0.26

Hydrophobic Moment 1.12

Boman Index-0.13

Instability Index69.39

Aliphatic Index 110.26

Aromaticity 0.0513

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1809.59

LogP -14.14

H-bond Donors 68.0

H-bond Acceptors 55.0

Rotatable Bonds 154.0

Heavy Atoms 302.0

Ring Count 3.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393549 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configside-chain cyclized/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermCAA, Chloroacetic acid

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMCF-7

Activity16±0.5 μM

MethodCC50

RECORD: Rec_0416167 VERIFIED: YES