Peptide Database

Peptide NameC34S[138A]

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC184H280N50O63S

DescriptionStandard

        WMEWDREINNYTSLIHSLIEEAQNQQEKNEQELL
    

Molecular Weight4232.55 Da

Isoelectric Point (pI)4.21

Net Charge (pH 7.0)-6.13

Net Charge (pH 7.4) -6.40

Charge Density (pH 7.0) -0.1804

GRAVY Index-1.19

Hydrophobic Moment 0.58

Boman Index-0.17

Instability Index59.78

Aliphatic Index 83.24

Aromaticity 0.0882

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1895.84

LogP -17.30

H-bond Donors 62.0

H-bond Acceptors 59.0

Rotatable Bonds 146.0

Heavy Atoms 298.0

Ring Count 6.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0366334 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 (NL4-3N43D) | HeLa cells

Activity0.002±0.0006 μM

MethodEC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperDesign of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. | Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. | J Biol Chem. 2009 Feb 20;284(8):4914-20. | DOI:10.1074/jbc.M807169200 | PMID:19073606 PMID19073606 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19073606/

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