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MYP_135158
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Basic Information
Dominulin B
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C89H151N23O23
Standard
Sequence
INWKKIAEIGKQVLSAL
Physicochemical Analysis
1911.29 Da
9.70
1.76
1.55
0.1035
0.27
0.71
0.17
14.12
143.53
0.0588
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
766.48
-4.18
26.0
25.0
67.0
135.0
2.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0271709 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0336631 VERIFIED: YES
Provenance & Taxonomy
Polistes dominula [Animal]
MCD; Mastoparan subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Bacillus subtilis
PMID16446098 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16446098/
RECORD: Rec_0388808 VERIFIED: YES
Provenance & Taxonomy
Polistes dominulus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli JM109
8 μg/mL
MIC
PMID16446098 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16446098/
RECORD: Rec_0400155 VERIFIED: YES
Provenance & Taxonomy
Polistes dominula [Animal]; Vespa dominula [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
2 μg/mL
MIC
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