Peptide Database

Peptide NamegerPF signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Alkaline protease secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC180H283N43O54S2

DescriptionStandard

        MSFMPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSAL
    

Molecular Weight3977.56 Da

Isoelectric Point (pI)8.25

Net Charge (pH 7.0)0.50

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0128

GRAVY Index0.58

Hydrophobic Moment 0.42

Boman Index0.33

Instability Index66.61

Aliphatic Index 90.00

Aromaticity 0.1026

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1520.57

LogP -17.23

H-bond Donors 52.0

H-bond Acceptors 57.0

Rotatable Bonds 126.0

Heavy Atoms 279.0

Ring Count 7.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231537 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis subsp. subtilis str. 168 [Bacterium]

FamilyTat signal peptide

Tax ID224308

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Alkalineprotease (alk) secretion

TargetBacillus amyloliquefaciens 111018

Activity318.5 U/mL

MethodProtease activity assay

PaperLiu Y, Shi C, Li D, et al. Engineering a highly efficient expression system to produce BcaPRO protease in Bacillus subtilis by an optimized promoter and signal peptide[J]. International journal of biological macromolecules, 2019, 138: 903-911. PMID31356949 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31356949/