Peptide Database

Peptide NameSLAY-screened peptide P4909

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H159N29O29S2

DescriptionStandard

        HCPPPFYMLESKTGRYNHYV
    

Molecular Weight2439.77 Da

Isoelectric Point (pI)8.17

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0462

GRAVY Index-0.86

Hydrophobic Moment 0.36

Boman Index-0.04

Instability Index109.88

Aliphatic Index 34.00

Aromaticity 0.2000

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 916.67

LogP -6.33

H-bond Donors 32.0

H-bond Acceptors 34.0

Rotatable Bonds 70.0

Heavy Atoms 172.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0141234 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/