Peptide Database

Peptide NameCmpd 12

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Standard StatusStandard

Sequence Length3 amino acids

Chemical FormulaC14H29N7O4

DescriptionStandard

GKR

Molecular Weight359.42 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.5864

GRAVY Index-2.93

Hydrophobic Moment 1.06

Boman Index-1.18

Instability Index87.03

Aliphatic Index 0.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 209.44

LogP -2.61

H-bond Donors 8.0

H-bond Acceptors 6.0

Rotatable Bonds 13.0

Heavy Atoms 25.0

Ring Count 0.0

Amide Bonds 2.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0377631 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPhenylacetyl

C-TermAmidation

Other ModsPhenylacetyl

Bio-Activity Profile

Function

Antiviral Anti-ZIKV Replication inhibition

TargetZika virus(ZIKV)

Activity100 μM

Method% inhibition

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperSAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease. | Colarusso S, Ferrigno F, Ponzi S, Pavone F, Conte I, Abate L, Beghetto E, Missineo A, Amaudrut J, Bresciani A, Paonessa G, Tomei L, Montalbetti C, Bianchi E, Toniatti C, Ontoria JM. | Bioorg Med Chem. 2022 Mar 1;57:116631. | DOI:10.1016/j.bmc.2022.116631 | PMID:35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/

RECORD: Rec_0390508 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

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