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MYP_134885
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Basic Information
Cmpd 12
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Standard
3 amino acids
C14H29N7O4
Standard
Sequence
GKR
Physicochemical Analysis
359.42 Da
11.00
1.76
1.55
0.5864
-2.93
1.06
-1.18
87.03
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
209.44
-2.61
8.0
6.0
13.0
25.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0068117 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phenylacetyl
None
Phenylacetyl
Bio-Activity Profile
Antiviral Anti-ZIKV Replication inhibition
Zika virus(ZIKV)
100 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperSAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease. | Colarusso S, Ferrigno F, Ponzi S, Pavone F, Conte I, Abate L, Beghetto E, Missineo A, Amaudrut J, Bresciani A, Paonessa G, Tomei L, Montalbetti C, Bianchi E, Toniatti C, Ontoria JM. | Bioorg Med Chem. 2022 Mar 1;57:116631. | DOI:10.1016/j.bmc.2022.116631 | PMID:35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0245022 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0254065 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0256486 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
Zika virus
40 %
Inhibition
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
RECORD: Rec_0298412 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Zika virus
40 %
Inhibition
PaperPubMed PMID: 35123179 PMID35123179 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35123179/
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