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MYP_134831
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Basic Information
Temporin L[Pro3,DLeu9,Nle10](TL6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FVPWFSKFLXRIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is norleucine.
Bio-Activity Profile
Antiviral Anti-HPIV3 Replication inhibition
HPIV-3 | Vero cells
32.35 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0050745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is 2-aminoindane-2-carboxylic acid.
Bio-Activity Profile
Antiviral Anti-HPIV3 Replication inhibition
HPIV-3 | Vero cells
50 μM
IC90
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0051512 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'x' at position 10 is D-norleucine.
Bio-Activity Profile
Antiviral Anti-HPIV3 Replication inhibition
HPIV-3 | Vero cells
50 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0052490 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is norleucine
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Vero cells:CC50=64
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0054221 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is 2-aminoindane-2-carboxylic acid
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV-2:inhibition of replication in Vero cells
0.65 μM
IC50
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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