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MYP_134831
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Basic Information
Temporin L[Pro3,DLeu9,Nle10](TL6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FVPWFSKFLXRIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037743 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Tridecanoic acid
Amidation
The 'X' at position 10 is norleucine.; Tridecanoic acid
Bio-Activity Profile
Antiviral Anti-HSV Replication inhibition
HSV-1 | Vero cells
2.86 μM
IC90
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0041236 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Pentadecanoic acid
Nle, N-terminal: Pentadecanoic acid, C- terminal NH2, small case letters are D amino acids at 10; Nle, N-terminal: Pentadecanoic acid, C- terminal NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
SARS-CoV-2
0.48 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0043395 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
D-Nle, C- terminal NH2, small case letters are D amino acids at 10; D-Nle, C- terminal NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
[Refer Pubmed ID 28863356: Bacillus megaterium Bm11 (
25 μM
MIC
PMID28863356;35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28863356/
RECORD: Rec_0045124 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Pentadecanoic acid
Amidation
The 'X' at position 10 is norleucine.; Pentadecanoic acid
Bio-Activity Profile
Antiviral Anti-Influenza virus Replication inhibition
Influenza virus (H1N1,VR-1894) | MDCK cells
7.1 μM
IC90
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0045778 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'x' at position 10 is D-hydroxyproline (Hyp).
Bio-Activity Profile
Antiviral Anti-HSV Replication inhibition
HSV-2 | Vero cells
50 μM
IC90
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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