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MYP_134831
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Basic Information
Temporin L[Pro3,DLeu9,Nle10](TL6)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-Influenza virus
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV cross
Antiviral ▸ Anti-Paramyxovirus ▸ Anti-HPIV ▸ Anti-HPIV3 cross
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
FVPWFSKFLXRIL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0232188 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Nle, C- terminal NH2, small case letters are D amino acids at 10; Nle, C- terminal NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
[Refer Pubmed ID 35216177: HSV-1 (
32.35 μM
IC50
PMID28863356;35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28863356/
RECORD: Rec_0237000 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is norleucine.
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2 | Vero cells
0.53 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0237004 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is norleucine.
Bio-Activity Profile
Antiviral Anti-MeV Replication inhibition
Measles virus (MeV) | Vero/hSLAM cells
50 μM
IC90
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs. | Zannella C, Chianese A, Palomba L, Marcocci ME, Bellavita R, Merlino F, Grieco P, Folliero V, De Filippis A, Mangoni M, Nencioni L, Franci G, Galdiero M. | Int J Mol Sci. 2022 Feb 13;23(4):2060. | DOI:10.3390/ijms23042060 | PMID:35216177 PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0238435 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Palmitoylation
Nle, N-terminal: Palmitic acid, C- terminal NH2, small case letters are D amino acids at 10; Nle, N-terminal: Palmitic acid, C- terminal NH2, small case letters are D amino acids
Bio-Activity Profile
Antimicrobial Antifungal
HSV-1
3.13 μM
IC50
PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
RECORD: Rec_0239938 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Temporin
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
The 'X' at position 10 is 2-aminoindane-2-carboxylic acid
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
human erythrocytes
PaperBroad-Spectrum Antiviral Activity of the Amphibian Antimicrobial Peptide Temporin L and Its Analogs PMID35216177 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216177/
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