Peptide Database

Peptide NameJEV(1965-1975)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus

Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC48H82N20O17

DescriptionStandard

        RVGRNPNQVGD
    

Molecular Weight1211.29 Da

Isoelectric Point (pI)9.60

Net Charge (pH 7.0)0.76

Net Charge (pH 7.4) 0.56

Charge Density (pH 7.0) 0.0695

GRAVY Index-1.55

Hydrophobic Moment 0.74

Boman Index-0.47

Instability Index-11.45

Aliphatic Index 52.73

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 635.90

LogP -9.66

H-bond Donors 21.0

H-bond Acceptors 18.0

Rotatable Bonds 39.0

Heavy Atoms 85.0

Ring Count 1.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0404663 VERIFIED: YES

Provenance & Taxonomy

OrganismHepatitis C virus [Virus]

FamilyVirus-derived peptide

Tax ID3052230;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Replication inhibitor

TargetHepatitis C virus (Replication); Vero

Activity374 μM

MethodHelicase assay

PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/

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