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MYP_134762
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Basic Information
hPF4
Antimicrobial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Chemokine signaling ▸ Chemokine-like peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
Standard
70 amino acids
C341H580N96O101S4
Standard
Sequence
EAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES
Physicochemical Analysis
7769.10 Da
8.80
2.98
2.63
0.0425
-0.21
0.68
-0.05
40.72
108.71
0.0143
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3183.20
-29.44
112.0
110.0
267.0
542.0
7.0
74.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0094146 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic
PaperPlatelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials.
RECORD: Rec_0104498 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22401766 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22401766/
RECORD: Rec_0245415 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
PaperPubMed PMID: 23245326 PMID23245326 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23245326/
RECORD: Rec_0294411 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiparasitic Antiprotozoal
Plasmodium falciparum
PMID23245326 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23245326/
RECORD: Rec_0303895 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
intercrine alpha (chemokine CxC) family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
10-36; 12-52
26-Ser: Phosphoserine
Bio-Activity Profile
Cytokine Growth factor intercrine alpha (chemokine CxC) family Chemokine-like Angiogenic Heparin-binding
PaperPDB 1PFM structural record; NMR; chain A/B/C/D; residues 8-70