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MYP_134748
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Basic Information
Brevinin-2GHb (AMP-2; Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
30 amino acids
C132H232N40O40S2
Standard
Sequence
GVITDALKGAAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
3083.63 Da
9.31
2.83
2.54
0.0942
0.21
0.59
0.05
7.79
104.33
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1300.49
-14.66
48.0
46.0
106.0
214.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002845 VERIFIED: YES
Provenance & Taxonomy
Rana guentheri [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus FDA209P
16.5 μg/mL
MIC
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
RECORD: Rec_0017710 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
5.4 μM
MIC
PaperJ. Zhou et al. / Peptides 27 (2006) 3077-3084. Purification and characterization of novel antimicrobial peptides from the skin secretion of Hylarana guentheri Evidence URLhttps://www.uniprot.org/uniprotkb/A0AEI5/entry
RECORD: Rec_0037114 VERIFIED: NO
Provenance & Taxonomy
Rana guentheri,Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0056729 VERIFIED: YES
Provenance & Taxonomy
Rana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis ATCC 6633
64 μg/mL
MIC
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
RECORD: Rec_0079144 VERIFIED: YES
Provenance & Taxonomy
Rana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
8.2 μg/mL
MIC
PMID16979798 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16979798/
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