Peptide Database

Peptide NameDX600

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Neurological / Signaling ▸ Signaling peptide

Other / Curated residual function label ▸ Generic enzyme inhibition annotation

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC139H184N34O40S2

DescriptionStandard

        GDYSHCSPLRYYPWWKCTYPDPEGGG
    

Molecular Weight3035.28 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-1.17

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.0451

GRAVY Index-1.18

Hydrophobic Moment 0.27

Boman Index-0.03

Instability Index69.97

Aliphatic Index 15.00

Aromaticity 0.2308

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 17085.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1157.35

LogP -9.25

H-bond Donors 42.0

H-bond Acceptors 42.0

Rotatable Bonds 83.0

Heavy Atoms 215.0

Ring Count 13.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357561 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Termacetylated

C-Termamidated

Other ModsN-terminal acetylation; C-terminal amidation

Bio-Activity Profile

Function

Enzyme inhibitory Vasoactive Signaling peptide

TargetAngiotensin-converting enzyme 2 (Human); Angiotensin-converting enzyme 2 (Mouse)

Activity2.8 nM

MethodKi