Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length436 amino acids

Chemical FormulaC2184H3426N582O631S14

DescriptionStandard

        MMARPYCVVVALLLLAEVSRLGEGASNPGFVVRITRKGLEYARQYGMAILKKELSTINVPDLSGSFEVGWMGSVSYEFKSTLQGTFDLSVDGVSISIYLNLGEDGNGRPTASVAHCSNSVGHVSIHISGNLSWLLNLFHKRIENKLKDILKQEICEIIRTSTSSHLEPYLRTLPVTLMIDEVAGIDYSLVGAPQVTSQGLDTPFRGEFFGRSQRSPVPFDAPPIRLPQQHDRMAYFAVSQYVFNTASRVYHQAGHMNFTIRNEDSPLNFPNRLHTKSLGAVIPQLARLYPNTELELEMSPESAPFLMFTPGNVTCVPVMNIQAFALLPNSSNRKPLFQLRARTDISATISVSSGRVLGSLTPGSKLKLELKHSNIGFFDVQLLESIFNYYASYIIYPSLNAKLEKGFPLPLPRDTYLSSLELQVHKNFLFVGADID
    

Molecular Weight48380.99 Da

Isoelectric Point (pI)7.72

Net Charge (pH 7.0)1.47

Net Charge (pH 7.4) 0.54

Charge Density (pH 7.0) 0.0034

GRAVY Index-0.02

Hydrophobic Moment 0.84

Boman Index0.10

Instability Index41.12

Aliphatic Index 96.12

Aromaticity 0.0940

Extinction Coeff. Reduced 34840.00

Extinction Coeff. Oxidized 35090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0143186 VERIFIED: NO

Provenance & Taxonomy

OrganismMyotis davidii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence