Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Standard StatusStandard

Sequence Length51 amino acids

Chemical FormulaC235H382N64O78S6

DescriptionStandard

        MNAMKNSKDILNNAIEEVSEKELMEVAGGKRGPGWIATITDDCPNSIFVCC
    

Molecular Weight5544.32 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-3.52

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0689

GRAVY Index-0.18

Hydrophobic Moment 0.57

Boman Index0.04

Instability Index44.04

Aliphatic Index 78.43

Aromaticity 0.0392

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2297.51

LogP -24.80

H-bond Donors 79.0

H-bond Acceptors 81.0

Rotatable Bonds 188.0

Heavy Atoms 383.0

Ring Count 5.0

Amide Bonds 55.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086950 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus salivarius [Bacterium]

FamilyLantibiotic

Structure & Mods

Configthioether-cyclized lantibiotic scaffold [Cyclic]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLanthionine/methyllanthionine-type thioether crosslinks are implied by the lantibiotic annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive

TargetGram-positive bacteria