Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length457 amino acids

Chemical FormulaC2341H3693N617O632S17

DescriptionStandard

        MSPVDSFIALWSHLKALRSWQLWRMREDVARGLHDAPRWASLLVLVAVGTTVTAATNPGVMVRISQKGLDYASQQGTAALQKELKRIKIPDYSGRFKIKLLGKGRYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKARKHFMWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHSPPPFAPAVMEFPAAHDHMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIQIHVSASAPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGVSTTASMEVGAKSDRLVGKLKVDRLILELKHSNIGPFPVELLQAIMNYVVPTFVLPRVNEKLQKGFPLPTPARVQLYNTVLQPHQNFLLFGADVVHK
    

Molecular Weight51138.22 Da

Isoelectric Point (pI)9.88

Net Charge (pH 7.0)22.55

Net Charge (pH 7.4) 21.61

Charge Density (pH 7.0) 0.0493

GRAVY Index-0.01

Hydrophobic Moment 0.82

Boman Index0.09

Instability Index39.28

Aliphatic Index 93.41

Aromaticity 0.0985

Extinction Coeff. Reduced 52370.00

Extinction Coeff. Oxidized 52370.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058722 VERIFIED: NO

Provenance & Taxonomy

OrganismCercocebus atys [Animal]

FamilyBPI

Tax ID9531

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence