Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length459 amino acids

Chemical FormulaC2293H3659N577O634S18

DescriptionStandard

        MLYSFLCVSELKMFPWRWLALLALIPLSLSANAGVKVKLTQKGLDFGRELFVASLQEKLMTIKVPDISGTERVDPIGKVHYSLTEMRIVKLGLPSSAIGLVPGTGFTMTITNAFLSLHGKWRVKYLRFIKDSGSFDLAIKSLSITTSISLRSDETGRPAVAVASCATTLGGVSIKFHGGASWLYNLFTRFIEKGLCSSLQKQICPLVAESVSSMNQFLKTLNVLAPLDRYAEIAYPMVSSPEISNSSIGLNLKGEFYNIGHHMEPPFSPAPFFLPNQEQSMLYIGLSVFTANSASFVYNKAGTLSLNITDDMIPPSSPFRLTTRTFGAFIPQIAKLFPGLMMVLQVKTAKDPLFNIEANNVTVDAISSLTAYAILANTSLAPLFVLNVVGSLKMTPDLCVGPLHNIFQIVLKVAVLPRVNVRLKEGFPLPSLGKINLTNTQLQVLKGYILIGTDLQISG
    

Molecular Weight50031.23 Da

Isoelectric Point (pI)9.40

Net Charge (pH 7.0)11.99

Net Charge (pH 7.4) 11.31

Charge Density (pH 7.0) 0.0261

GRAVY Index0.35

Hydrophobic Moment 0.73

Boman Index0.21

Instability Index40.01

Aliphatic Index 109.17

Aromaticity 0.0893

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296706 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence