Peptide Database

Peptide NamePoca B

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC130H210N34O39S6

DescriptionStandard

        GIPCAESCVFIPCVTAILGCSCKDRVCYN
    

Molecular Weight3065.65 Da

Isoelectric Point (pI)6.03

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0103

GRAVY Index0.86

Hydrophobic Moment 0.27

Boman Index0.25

Instability Index24.58

Aliphatic Index 90.69

Aromaticity 0.0690

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1147.07

LogP -11.82

H-bond Donors 45.0

H-bond Acceptors 45.0

Rotatable Bonds 94.0

Heavy Atoms 209.0

Ring Count 4.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0046883 VERIFIED: YES

Provenance & Taxonomy

OrganismPombalia calceolaria [Plant]

FamilyCyclotide

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Cytotoxic

TargetMDA-MB-231

Activity1.8 μM

MethodIC50