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MYP_134369
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Basic Information
Indolicidin [R12P][R13P]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
13 amino acids
C98H121N19O14
Standard
Sequence
ILPWKWPWWPWPP
Physicochemical Analysis
1789.13 Da
8.75
0.76
0.55
0.0584
-0.62
0.14
0.43
47.03
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
473.54
6.59
15.0
15.0
38.0
131.0
15.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0220024 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
16 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0384232 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Indolicidin
9913
Structure & Mods
branched peptide architecture [Branched]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
16 μM
IC50
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0423527 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
13 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
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