‹ ›
MYP_134369
← PREVIOUS NEXT → BACK
Basic Information
Indolicidin [R12P][R13P]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Standard
13 amino acids
C98H121N19O14
Standard
Sequence
ILPWKWPWWPWPP
Physicochemical Analysis
1789.13 Da
8.75
0.76
0.55
0.0584
-0.62
0.14
0.43
47.03
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
473.54
6.59
15.0
15.0
38.0
131.0
15.0
12.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0072400 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0103189 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Indolicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Integrase inhibition
60 μM
IC50
PaperCovalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites. PMID16998183 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16998183/
RECORD: Rec_0178586 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
13 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0181336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
16 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0186501 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 53.8%, C 46.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2