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MYP_134346
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Basic Information
IBP20
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C192H317N51O63
Standard
Sequence
SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
Physicochemical Analysis
4347.87 Da
4.77
-2.53
-2.76
-0.0684
-0.60
0.70
-0.12
40.54
121.08
0.0541
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1920.55
-16.88
63.0
61.0
156.0
306.0
2.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0071006 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Chol(cholesterol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
HCoV-NL63:inhibition of pseudovirus infections in Huh-7 cells
0.81721 μM
IC50
PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/
RECORD: Rec_0075193 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG5-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
MERS-CoV:inhibition of pseudovirus infections in Huh-7 cells
0.0485 μM
IC50
PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/
RECORD: Rec_0075896 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG5-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of pseudovirus infections in 293T/ACE2 cells
0.00213 μM
IC50
PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/
RECORD: Rec_0081462 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG8-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion
0.00032 μM
IC50
PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/
RECORD: Rec_0084631 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
C16(palmitic acid)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
inhibition of pseudovirus infections in Huh-7 cells
0.12665 μM
IC50
PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/
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