Peptide Database

Peptide NameIBP20

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC192H317N51O63

DescriptionStandard

        SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
    

Molecular Weight4347.87 Da

Isoelectric Point (pI)4.77

Net Charge (pH 7.0)-2.53

Net Charge (pH 7.4) -2.76

Charge Density (pH 7.0) -0.0684

GRAVY Index-0.60

Hydrophobic Moment 0.70

Boman Index-0.12

Instability Index40.54

Aliphatic Index 121.08

Aromaticity 0.0541

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1920.55

LogP -16.88

H-bond Donors 63.0

H-bond Acceptors 61.0

Rotatable Bonds 156.0

Heavy Atoms 306.0

Ring Count 2.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426751 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermChol(cholesterol)

Other ModsChol(cholesterol)

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 E484K | Huh-7 cells

Activity0.07909 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperStructure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants. | Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y. | Emerg Microbes Infect. 2021 Dec;10(1):1227-1240. | DOI:10.1080/22221751.2021.1937329 | PMID:34057039 PMID34057039 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34057039/

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