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MYP_134333
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Basic Information
Humimycin B
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Standard
7 amino acids
C45H61N7O13
Standard
Sequence
YSYYTIV
Physicochemical Analysis
908.00 Da
5.52
-0.24
-0.45
-0.0347
0.47
0.22
0.43
1.94
97.14
0.4286
4470.00
4470.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
339.07
-0.77
13.0
13.0
24.0
65.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027188 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Y3, T5 are D-amino acids. The N-terminus of the peptide is acylated with a C14 carbon fatty acid with hydroxylation at gamma carbon. Active against R. mucilaginosa, R. dentocariosa, Eubacterium spp., 3_1_31, S. aureus (MRSA), S. mitis, S. mutans, S. delphini, S. intermedius, S. pseudintermedius, S. pneumoniae, S. sanguinis (MIC 4-32 ug/ml). The original synthetic peptide has been replaced. 9/2020; 4/2024
Bio-Activity Profile
Antimicrobial Antifungal
S. mitis, S. mutans, S. delphini, S. intermedius, S. pseudintermedius, S. pneumoniae, S. sanguinis
4-32 μg/mL
MIC
PaperDiscovery of MRSA active antibiotics using primary sequence from the human microbiome
RECORD: Rec_0055756 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus mutans
8 μg/mL
MIC
PMID27748750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27748750/
RECORD: Rec_0114412 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis
16 μg/mL
MIC
PMID27748750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27748750/
RECORD: Rec_0186512 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
4 μg/mL
MIC
PMID27748750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27748750/
RECORD: Rec_0188682 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
R . mucilaginosa
8 μg/mL
MIC
PMID27748750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27748750/
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