Peptide Database

Peptide NameSLAY-screened peptide P4552

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC92H135N25O37S

DescriptionStandard

        PMDSSNDGSYNEGHKSIDYV
    

Molecular Weight2215.27 Da

Isoelectric Point (pI)4.22

Net Charge (pH 7.0)-2.95

Net Charge (pH 7.4) -3.07

Charge Density (pH 7.0) -0.1476

GRAVY Index-1.28

Hydrophobic Moment 0.50

Boman Index-0.15

Instability Index36.83

Aliphatic Index 34.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1013.69

LogP -14.25

H-bond Donors 35.0

H-bond Acceptors 36.0

Rotatable Bonds 72.0

Heavy Atoms 155.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084264 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/