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MYP_134287
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Basic Information
MCo-SST-01
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C152H250N48O45S6
Standard
Sequence
CPKILKKCRRDSDCPGACICRYWKVCGSGSDGGV
Physicochemical Analysis
3662.30 Da
8.90
3.70
3.40
0.1088
-0.34
0.69
-0.14
50.51
54.41
0.0588
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1504.43
-18.01
60.0
55.0
120.0
251.0
5.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012123 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
100 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0036439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
Human red blood cells: no hemolytic activity(as show in Fig.4)
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0075673 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
85.44±0.08 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0077727 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
HT-29
74.13±0.07 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0171507 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/