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MYP_134265
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Basic Information
Pyronesin4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
40 amino acids
C191H279N53O55S7
Standard
Sequence
GFGCNGPWDEDDMKCHNHCKSIKGYKGGYCAKAGFVCKCY
Physicochemical Analysis
4422.04 Da
8.29
1.87
1.46
0.0468
-0.65
0.36
-0.04
16.63
22.00
0.1500
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1735.00
-17.90
65.0
66.0
144.0
306.0
10.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0255384 VERIFIED: YES
Provenance & Taxonomy
Pyronema confluens [Fungus]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus CGMCC 1.89
1.22 μM
MIC
PMID35205928 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35205928/
RECORD: Rec_0323335 VERIFIED: YES
Provenance & Taxonomy
Pyronema confluens [Fungus]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus J698
2.69 μM
MIC
PMID35205928 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35205928/
RECORD: Rec_0337107 VERIFIED: YES
Provenance & Taxonomy
Pyronema confluens [Fungus]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Penicillin-resistant Staphylococcus epidermidis P1389
4.38 μM
MIC
PMID35205928 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35205928/
RECORD: Rec_0338165 VERIFIED: YES
Provenance & Taxonomy
Pyronema confluens [Fungus]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Bacillus megaterium CGMCC 1.0459 (lethal conc CL 0.67 uM), C. luteum (LC 0.03 uM), Staphylococcus aureus CGMCC 1.89 (LC 1.22 uM), Penicillin-sensitive Staphylococcus epidermidis P1111 (LC 4.03 uM), Penicillin-resistant Staphylococcus epidermidis P1111 (LC 4.38 uM), Methicillin-resistant Staphylococcus aureus (MRSA) P1374 (LC 2.69 uM), Methicillin-resistant coagulase negative Staphylococci P1369 (CL 4.78 uM), MRSA P1386 (CL 2.51 uM), Staphylococcus aureus J685, Staphylococcus aureus J698 (CL 2.69 uM), Staphylococcus aureus J706 (CL 2.51 uM)
PaperA Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability.
RECORD: Rec_0364183 VERIFIED: YES
Provenance & Taxonomy
Pyronema confluens [Fungus]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus megaterium CGMCC 1.0459
0.67 μM
MIC
PMID35205928 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35205928/
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