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MYP_134215
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Basic Information
Defensin-related cryptdin 4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
32 amino acids
C158H263N57O38S6
Standard
Sequence
GLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR
Physicochemical Analysis
3761.53 Da
9.86
7.79
7.44
0.2433
-0.47
0.68
-0.32
25.82
57.81
0.0938
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1568.64
-16.04
66.0
53.0
125.0
259.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0301266 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μg/mL
Hemolysis
PaperGarcia AE, Tai KP, Puttamadappa SS, et al. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 6;50(48):10508-10519. doi:10.1021/bi201430f. PMID22040603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22040603/
RECORD: Rec_0333052 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
50 μg/mL
Hemolysis
PaperGarcia AE, Tai KP, Puttamadappa SS, et al. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 6;50(48):10508-10519. doi:10.1021/bi201430f. PMID22040603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22040603/
RECORD: Rec_0351881 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
10090
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
4-29, 6-21, 11-28
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0361631 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 31.2%, T 28.1%, C 40.6% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Hemolytic Anti-Gram-positive Antitrypanosomal Anti-Gram-negative
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0362756 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
0 μg/mL
Hemolysis
PaperGarcia AE, Tai KP, Puttamadappa SS, et al. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 6;50(48):10508-10519. doi:10.1021/bi201430f. PMID22040603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22040603/
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