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MYP_134215
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Basic Information
Defensin-related cryptdin 4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
32 amino acids
C158H263N57O38S6
Standard
Sequence
GLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR
Physicochemical Analysis
3761.53 Da
9.86
7.79
7.44
0.2433
-0.47
0.68
-0.32
25.82
57.81
0.0938
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1568.64
-16.04
66.0
53.0
125.0
259.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0123210 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PMID15595831 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15595831/
RECORD: Rec_0149554 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
12.5 μg/mL
Hemolysis
PaperGarcia AE, Tai KP, Puttamadappa SS, et al. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 6;50(48):10508-10519. doi:10.1021/bi201430f. PMID22040603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22040603/
RECORD: Rec_0193731 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
25 μg/mL
Hemolysis
PaperGarcia AE, Tai KP, Puttamadappa SS, et al. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 6;50(48):10508-10519. doi:10.1021/bi201430f. PMID22040603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22040603/
RECORD: Rec_0225424 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0227732 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei 427
50 μM
IC50; MTT assay
PaperAntimicrobial peptide killing of African trypanosomes PMID21517904 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21517904/
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