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MYP_134114
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Basic Information
Radical S-adenosyl methionine domain-containing protein 2
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV ▸ Anti-HSV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
361 amino acids
C1903H2975N517O533S17
Standard
Sequence
MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETKEEEEDPPLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKINFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISCDSFDEEVNVLIGRGQGKKNHVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTEQIKALNPVRWKVFQCLLIEGENCGEDALREAERFVIGDEEFERFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIWSKADLKLDW
Physicochemical Analysis
42169.23 Da
8.53
4.82
4.11
0.0134
-0.40
0.83
-0.07
51.61
85.29
0.1136
62910.00
63535.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060664 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Viperin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The Lys at position 197 idnicates N6-acetyllysine
Bio-Activity Profile
Antiviral Replication inhibitor Anti-HSV-1
Herpes simplex virus 1(HSV-1)
PaperThe Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin. PMID31921110 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31921110/
RECORD: Rec_0140533 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Viperin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The Lys at position 197 idnicates N6-acetyllysine
Bio-Activity Profile
Antiviral Replication inhibitor Anti-ZIKV Anti-WNV Anti-DENV Anti-HCV
Zika virus(ZIKV)/west nile virus(WNV)/dengue virus (DENV)/Hepatitis C virus(HCV)
PaperA naturally occurring antiviral ribonucleotide encoded by the human genome. PMID29925952 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29925952/
RECORD: Rec_0362191 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Viperin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
The Lys at position 197 idnicates N6-acetyllysine
Bio-Activity Profile
Antiviral Replication inhibitor Anti-EVA71
Enterovirus A71 (EVA71)
PaperViperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein. PMID30587778 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30587778/